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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 07-167 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-Blys/TALL-1/BAFF/THANK Antibody |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | PBS containing 0.05% BSA and 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Blys/TALL-1/BAFF/THANK Antibody is an antibody against Blys/TALL-1/BAFF/THANK for use in WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | peptide corresponding to amino acids 254-269 of human Blys (EEGDELQLAIPRENAQ) |
| Host | Rabbit |
| Specificity | Blys/TALL-1/BAFF/THANK |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. |
| Gene Symbol |
|
| Purification Method | Protein g Chromatography |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q9Y275 # Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. SIZE: 285 amino acids; 31223 Da SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. PTM: The soluble form derives from the membrane form by proteolytic processing. & N-glycosylated. SIMILARITY: SwissProt: Q9Y275 ## Belongs to the tumor necrosis factor family. |
| Molecular Weight | 32kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on RIPA lysates from Jurkat cells or HeLa nuclear extract |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |