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Millipore Anti-Mglur2 Antibody Is An Antibody Against Mglur2 For Use In Western Blotting, Immunoprecipitation. - Mill (Additional S&H or Hazmat Fees May Apply)
The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 belongs to the Group II. It is widely expressed in different regions of fetal and the adult brain. Ligand binding to GluR2 induces a conformation change in the receptor, which triggers signaling to modulate the activity of down-stream effectors, mainly via the inhibition of adenylate cyclase activity. Activation of mGluR2 leads to inhibition of glutamate release at the synaptic junction
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-mGluR2 Antibody is an antibody against mGluR2 for use in Western Blotting, Immunoprecipitation.
Key Applications
Western Blotting
Immunoprecipitation
Application Notes
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated mGlur2 in 500 µg of rat brain microsomal prep.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of mouse mGlur2.
Epitope
Cytoplasmic domain
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Rat
Species Reactivity Note
Rat. Predicted to react with Mouse based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_001153825
Gene Symbol
Grm2
Gprc1b
Mglur2
Purification Method
Affinity Purfied
UniProt Number
Q14BI2
Molecular Weight
~95/200 kDa observed. The lower band corresponds to the calculated molecular weight of mGluR2 (~100 kDa) and the upper band is likely a receptor dimer and frequently appears in immunoblots of mGluRs (Reid and Romano, 2001; Romano et al., 1996).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in rat brain microsomal prep.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected mGlur2 in 10 µg of rat brain microsomal prep.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
