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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | WB | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 07-674 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-Na+K+ ATPase α-2 Antibody |
| Product Information | |
|---|---|
| Format | Serum |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Na+K+ ATPase α-2 Antibody is an antibody against Na+K+ ATPase α-2 for use in WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na+K+ ATPase α-2, with an N-terminal cysteine added for conjugation purposes. |
| Host | Rabbit |
| Specificity | Na+/K+ ATPase α-2 |
| Isotype | IgG |
| Species Reactivity |
|
| Species Reactivity Note | Predicted to crossreact with human, mouse, dog and monkey based on sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. |
| Gene Symbol |
|
| Purification Method | Antiserum |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P50993 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. SIZE: 1020 amino acids; 112265 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DISEASE: SwissProt: P50993 # Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. & Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. SIMILARITY: SwissProt: P50993 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. |
| Molecular Weight | Mr 105kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144) |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 2 years at -20°C from date of shipment |
| Packaging Information | |
|---|---|
| Material Size | 200 µL |