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Millipore Use Anti-Ehmt1/Glp1 Antibody (Rabbit Polyclonal Antibody) Validated In Wb To Detect Ehmt1/Glp1 Also Known As H3-K9-Hmtase 5, Histone H3-K9 Methyltransferase 5. - Mill (Additional S&H or Hazmat Fees May Apply)
G9a-Like Protein 1 (GLP1), also known as Euchromatic histone lysine N-methyl-transferase 1 (EMHT1), is a histone methyltransferase that methylates Lys9 of histone H3. H3Lys9 methylation is a marker for epigenetic transcriptional repression. EMHT1/GLP1 is targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it contributes to silencing of Myc- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. EMHT1/GLP1 is phosphorylated upon DNA damage, probably by ATM or ATR. Defects in EHMT1 result in severe mental retardation, hypotonia, and epileptic seizures.
Use Anti-EHMT1/GLP1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EHMT1/GLP1 also known as H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH conjugated synthetic peptide (KHTQDSARVNPQDGTNTLTR(C) corresponding to a.a. 40-59 of human EMHT1/GLP1.
Epitope
a.a. 40-59
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Recognizes EMHT1/GLP1
Isotype
IgG
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_012117.1
79813
Gene Symbol
EHMT1
EUHMTASE1
KMT1D
KIAA1876
Purification Method
ImmunoAffinity Purified
UniProt Number
Q9H9B1
UniProt Summary
Histone methyltransferase. Methylates Lys-9 of histone H3 (in vitro). H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle.
Enzyme Number (IUBMB): EC 2.1.1.43
Molecular Weight
160 kda
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance
