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Millipore Active, N-Terminal 6his-Tagged, Recombinant, Human, Full Length Mnk2, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal 6His-tagged, recombinant, human, full length Mnk2
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal 6His-tagged, recombinant, human, full length Mnk2, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
expressed by baculovirus in Sf21 cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_017572.3
NM_199054.2
Gene Symbol
MKNK2
GPRK7
Mnk2
MNK2
Protein Target
Mnk2
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
CAMK
UniProt Number
Q9HBH9
UniProt Summary
FUNCTION: SwissProt: Q9HBH9 # May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. COFACTOR: Magnesium. & Binds 1 zinc ion per subunit. SIZE: 465 amino acids; 51875 Da SUBUNIT: Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2. Isoform 2 interacts with ESR2. TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. PTM: Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. SIMILARITY: SwissProt: Q9HBH9 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
Molecular Weight
50kDa
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of MBP (Catalog # 13-104)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
