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Use: Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
Product Information
Presentation
lyophilized powder
Quality Level
MQ100
Applications
Application
Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
Key Applications
Histone Deacetylase Assay (HDAC)
Biological Information
Entrez Gene Number
NM_005530.2
Entrez Gene Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
Gene Symbol
IDH3A
NAD
UniProt Number
P50213
UniProt Summary
COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity). SIZE: 366 amino acids; 39592 Da SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: SwissProt: P50213 ## Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
