Special Offers
100% Performance Guaranteed
Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R, H | WB, ICC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB10140 |
| Description | Anti-Drebrin A/E Antibody |
| Alternate Names |
|
| Background Information | The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal antibody in PBS with 0.05% NaN3. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC. |
| Key Applications |
|
| Application Notes | Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University. |
| Biological Information | |
|---|---|
| Immunogen | KLH conjugated synthetic linear peptide. |
| Epitope | Internal Domain |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | Cat. # AB10140 detects the internal domain of Drebrin A/E. |
| Species Reactivity |
|
| Species Reactivity Note | Mouse and Rat. May react with human based on sequence homology. Reactivity with other species has not been determined. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimers disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq] |
| Gene Symbol |
|
| Purification Method | Antigen Affinity Purified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. SUBUNIT STRUCTURE: Binds F-actin. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Brain neurons. MISCELLANEOUS: Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals. SEQUENCE SIMILARITIES: Contains 1 ADF-H domain. |
| Molecular Weight | ~77 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Western Blot: A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8ºC from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |