Special Offers
100% Performance Guaranteed
Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB10428 |
| Description | Anti-Kallikrein-3 (KLK3) (CT) Antibody |
| Alternate Names |
|
| Background Information | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified in PBS with 0.09% NaN3. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Kallikrein-3 (KLK3) (C-term) Antibody is validated for use in WB for the detection of Kallikrein-3 (KLK3) (C-term). |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human KLK3. |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | The antibody reacts with the 29 kDa KLK3 antigen. |
| Species Reactivity |
|
| Species Reactivity Note | Reacts with human, mouse and rat. Other species have not been tested. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. [provided by RefSeq] |
| Gene Symbol |
|
| Purification Method | Saturated Ammonium Sulfate (SAS) |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. CATALYTIC ACTIVITY: Preferential cleavage: -Tyr-|-Xaa-. SUBCELLULAR LOCATION: Secreted. SEQUENCE SIMILARITIES: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. |
| Molecular Weight | ~31 kDa observed. Band may migrate from the calculated 29 kDa to ~31 kDa on western blot. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Western Blot Analysis: 1:250 dilution of this antibody detected KLK3 on mouse brain lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20° |
| Packaging Information | |
|---|---|
| Material Size | 400 µl |