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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | ICC, IHC | Ch | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB15454 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Proteolipid Protein Antibody |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Liquid in PBS, pH 7.2 with 0.02% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Proteolipid Protein using this Anti-Proteolipid Protein Antibody validated for use in IC, IH. |
| Key Applications |
|
| Application Notes | Immunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue. Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells. Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide corresponding to human/mouse PLP protein. |
| Host | Chicken |
| Specificity | PLP [Proteolipid Protein] |
| Species Reactivity |
|
| Species Reactivity Note | Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| Gene Symbol |
|
| Purification Method | ImmunoAffinity Purified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. SIZE: 277 amino acids; 30077 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DISEASE: SwissProt: P60201 # Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia. & Defects in PLP1 are the cause of spastic paraplegia type 2 (SPG2) [MIM:312920]. SPG2 is a form of X-linked hereditary spastic paraplegia (HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Additional features include nystagmus, dysarthria and mental retardation, that are found in the complicated form of spastic paraplegia. SIMILARITY: SwissProt: P60201 ## Belongs to the myelin proteolipid protein family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 500 µL |