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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, Mk, R, Rb, Fe | IHC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB1570 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-GABA Transporter-1 Antibody, CT (a.a. 588-599) |
| Alternate Names |
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| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Affinity purified antibody. Lyophilized from in 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-GABA Transporter-1 Antibody, C-terminus (a.a. 588-599) is an antibody against GABA Transporter-1 for use in IH. |
| Key Applications |
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| Applications Not Recommended |
|
| Application Notes | Immunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed or 4% paraformaldehyde and 0.2% glutaraldehyde fixed tissue. It is recommended that the antibody be diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1570 has been used for both light and electron microscopic studies of rat retina, cortex and hippocampus. Note: AB1570 is not recommended for Western blot use. See AB1570W. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Rat GAT-1, C-terminus (aa 588-599) |
| Epitope | C-terminus (a.a. 588-599) |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | GABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P30531 # Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. SIZE: 599 amino acids; 67015 Da SUBUNIT: Interacts with MPP5 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). DOMAIN: SwissProt: P30531 The PDZ domain-binding motif is involved in the interaction with MPP5. SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family. MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 10 µg |