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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | IP, WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB1592P |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Anti-NMDAR2C Antibody, also recognizes NMDAR2A and 2B |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mm), some residual salt may be present. Reconstitute with 50 μL of PBS. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect NMDAR2C using this Anti-NMDAR2C Antibody, also recognizes NMDAR2A & 2B validated for use in IP & WB. |
| Key Applications |
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| Applications Not Recommended |
|
| Application Notes | Western blotting 1:100-1:200 Immunoprecipitation: 3 μL will (under the appropriate conditions) quantitatively immunoprecipitate all NMDAR2C in 200 μg of rat cerebellum. Not recommended for use in immunohistochemistry since the antibody also reacts with NMDAR2A and NMDAR2B. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | N-Terminal Fusion Protein of the NMDAR2C |
| Epitope | N-terminus |
| Host | Rabbit |
| Specificity | NMDAR2C. Immunolabels the 140 kD NMDAR2C subunit of the NMDA receptor. Also reacts with NMDAR2A and NMDAR2B by Western blot (180 kD). |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). |
| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: Q14957 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. SIZE: 1233 amino acids; 134240 Da SUBUNIT: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Mainly in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. SIMILARITY: SwissProt: Q14957 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain lyophilized antibody at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 10 µg |