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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB, IH(P) | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB19011 |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Anti-Tenascin Antibody |
| Alternate Names |
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| Background Information | Tenascin is known to play an active role in development of central nervous system and mesenchymal-derived organs, exist in the vasculature of tumors in adults, and function in cell adhesion. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Affinity purified using immobilized human tenascin; presented as a liquid in PBS containing no preservatives. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Tenascin Antibody is validated for use in WB, IH(P) for the detection of Tenascin. |
| Key Applications |
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| Application Notes | Western blot: 0.5 - 1.0 μg/mL; recognizes 250-350 kDa polypeptides in reduced samples. Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Purified human tenascin from glioma culture supernatant. |
| Host | Rabbit |
| Specificity | Reacts strongly with tenascin from human and mouse in both Western blotting and immunohistochemistry. While it has not been tested, it should also react strongly in these applications with tenascin from all mammalian species. |
| Species Reactivity |
|
| Species Reactivity Note | Reactivity with other species has not been confirmed, but likely to react with all mammalian species. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. SIZE: 2201 amino acids; 240866 Da SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. PTM: N-glycosylated (By similarity). SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C for up to 12 months from date of receipt. Aliquot to avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 50 µg |