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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | ELISA, WB | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB3542 |
| Replaces | AB3542P |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Monocarboxylate Transporter 2 Antibody |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Serum |
| Presentation | Rabbit serum. Liquid. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Monocarboxylate Transporter 2 Antibody is an antibody against Monocarboxylate Transporter 2 for use in ELISA & WB. |
| Key Applications |
|
| Application Notes | Western blot ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG218) per well. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | A 15 amino acid peptide sequence near the C-terminus of rat MCT2 (Jackson et al. 1997; Dao et al. 1998; Koehler-Stec et al. 1998; Price et al. 1998; Halestrap & Price 1999). |
| Host | Rabbit |
| Specificity | Recognizes rat Monocarboxylate Transporter 2 (MCT2). The immunogen shows no significant sequence homology with other MCT. The immunogen sequence is 93% conserved in mouse and 66% in hamster. Reactivity with other species has not been confirmed. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: O60669 # Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. SIZE: 478 amino acids; 52186 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells. SIMILARITY: SwissProt: O60669 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |