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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| Ma | ELISA, WB, ICC, IHC | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB5354 |
| Replaces | 04-1032 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Internexin α Antibody |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Serum liquid, containing no preservatives. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Internexin Antibody, α is an antibody against Internexin for use in ELISA, WB, IC, IH. |
| Key Applications |
|
| Application Notes | Immunohistochemistry on formalin or paraformaldehyde fixed tissues. Immunocytochemistry. Western blot: using human or rat brain homogenates. ELISA Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Full length recombinant rat alpha-internexin fused to E. coli Trp E. |
| Host | Rabbit |
| Specificity | alpha-internexin, C-terminal globular "tail" region. By western blot, AB5354 detects a major band at 66 kDa and a minor band at approximately 150 kDa corresponding to alpha internexin monomer and dimer, respectively. A minor band at approximately 50 kDa is occasionally detected and is believed to be a degradation product of alpha internexin. This antibody has been referred to in the literature as the R36 antibody (Evans, 2002). |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q16352 # Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. SIZE: 499 amino acids; 55391 Da TISSUE SPECIFICITY: Found predominantly in adult CNS. DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation. PTM: O-glycosylated (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: SwissProt: Q16352 ## Belongs to the intermediate filament family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |