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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R, Pm | ICC, IHC, WB | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB5511 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Opioid Receptor Antibody, µ, pain |
| Alternate Names |
|
| Background Information | Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et Al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et Al., 2002). |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Rabbit polyclonal serum in buffer containing 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB. |
| Key Applications |
|
| Application Notes | Immunohistochemistry: 1:2,500-1:5,000 dilution of a previous lot was used. Western blot: 1:1,000 dilution of a previous lot was used. Immunocytochemistry: 1:2,500-1:5,000 dilution of a previous lot was used. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide from the C-terminus of rat Mu Opioid receptor. |
| Epitope | C-terminus |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | Mu Opioid receptor. |
| Species Reactivity |
|
| Species Reactivity Note | Human, rat, mouse and primate. Other species have not been tested. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Unpurified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P35372 # Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin. SIZE: 400 amino acids; 44779 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P35372 ## Belongs to the g-protein coupled receptor 1 family. |
| Molecular Weight | 45 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot on Human Liver lysate. Western Blot Analysis: 1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at -20ºC from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |