The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
NETA ALERT: Due to inclement weather our offices are closed today, Monday Feb. 23. We will not be shipping orders.
Millipore Anti-Gaba A Receptor Beta2 Antibody, Cytoplasmic Loop
Millipore Anti-Gaba A Receptor Beta2 Antibody, Cytoplasmic Loop
List Price$655.20Your Price$655.20
Millipore Anti-Gaba A Receptor Β2 Antibody, Cytoplasmic Loop Is An Antibody Against Gaba A Receptor Β2 For Use In Ip & Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-GABA A Receptor β2 Antibody, cytoplasmic loop
Product Information
Format
Affinity Purified
Presentation
Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.2 mg/mL.
Quality Level
MQ100
Applications
Application
Anti-GABA A Receptor β2 Antibody, cytoplasmic loop is an antibody against GABA A Receptor β2 for use in IP & WB.
Key Applications
Immunoprecipitation
Western Blotting
Application Notes
Western blot: 1:1,000
Immunopreciptation: The antibody will immunoprecipitate 68% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
MBP fusion protein from the cytosolic loop of rat GABAA receptor beta2 subunit.
Epitope
cytoplasmic loop
Host
Rabbit
Specificity
GABAA receptor beta2 subunit. The antibody is specific for the ~50 to 56kDa in rat brain membrane fractions.
Species Reactivity
Bovine
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_000813.2
NM_021911.2
Entrez Gene Summary
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
Gene Symbol
GABRB2
MGC119386
GABA
MGC119389
MGC119388
UniProt Number
P47870
UniProt Summary
FUNCTION: SwissProt: P47870 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SIZE: 474 amino acids; 54606 Da SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P47870 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
