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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ch, H, M | WB, IH(P) | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB907 |
| Replaces | 04-585 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Desmin Antibody |
| Product Information | |
|---|---|
| Format | Serum |
| Presentation | Rabbit antiserum. Liquid containing 0.1% sodium azide as a preservative. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Desmin Antibody is an antibody against Desmin for use in WB, IH(P). |
| Key Applications |
|
| Application Notes | Indirect immunofluorescence of formalin fixed paraffin-embedded sections of human intestine sections: 1:10-1:20. Immunoblotting Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Purified desmin from chicken gizzard, isolated by modified procedure of Geisler, et al [J. Biol Chem. (1980). 111:425-433]. |
| Host | Rabbit |
| Specificity | Desmin. Reacts specifically with desmin in cultured cells or tissue preparations originating from chicken, human, bovine and mouse tissue. AB907 specifically stains the wide desmin band in immunoblot at a molecular weight of 50-55 kD. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. SIZE: 470 amino acids; 53536 Da SUBUNIT: Homopolymer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 500 µL |