Special Offers
100% Performance Guaranteed
Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB9600 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Neuropilin-1 Antibody |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Affinity purified immunoglobulin in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Neuropilin-1 Antibody is an antibody against Neuropilin-1 for use in WB. |
| Key Applications |
|
| Application Notes | Western blot: 1:500 on transfected COS-7 cells. The antibody reacts with the ~130 kDa protein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04% Tween 20. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide from the N-terminal CUB domain of human neuropilin-1. |
| Host | Rabbit |
| Specificity | Neuropilin-1. The immunogen sequence has low homology with neuropilin-2. |
| Species Reactivity |
|
| Species Reactivity Note | It is expected that the antibody will also react with rat and mouse. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: O14786 # The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. SIZE: 923 amino acids; 103120 Da SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted. TISSUE SPECIFICITY: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. SIMILARITY: SwissProt: O14786 ## Belongs to the neuropilin family. & Contains 2 CUB domains. & Contains 2 F5/8 type C domains. & Contains 1 MAM domain. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |