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Affinity purified immunoglobulin. Liquid in 10 mm HEPES (pH 7.5), 150 mm NaCl, 100 μg/mL BSA and 50% glycerol.
Quality Level
MQ100
Applications
Application
Anti-GABA A Receptor α 5 Antibody is an antibody against GABA A Receptor α 5 for use in WB.
Key Applications
Western Blotting
Application Notes
Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Fusion protein from the Cytosolic loop of rat the GABAA Receptor alpha 5 subunit.
Host
Rabbit
Specificity
GABAA Receptor alpha 5 subunit. The antibody recognizes a protein of ~55 kDa corresponding to GABAA Receptor alpha 5 subunit in lysates from rat hippocampus and thalamus.
Species Reactivity
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_000810.2
Entrez Gene Summary
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
Gene Symbol
GABRA5
GABA
MGC138184
Purification Method
ImmunoAffinity Purified
UniProt Number
P31644
UniProt Summary
FUNCTION: SwissProt: P31644 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SIZE: 462 amino acids; 52146 Da SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P31644 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
