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Millipore Anti-Pdl-1 Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Programmed Cell Death 1 Ligand 1 & Has Been Tested In Western Blotting, Ihc (Paraffin) & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Programmed cell death 1 ligand 1 (PDL-1) is a B7 related protein belonging to the BTN/MOG family. PDL-1 is essential for T-cell proliferation and production of IL10 and IFNG. PDL-1 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PDL-1 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PDL-1 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver.
Product Information
Format
Affinity Purified
Control
Raji cell lysate
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-PDL-1 Antibody is a highly specific rabbit polyclonal antibody, that targets Programmed cell death 1 ligand 1 & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Immunofluorescence
Application Notes
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PDL-1 in human heart tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PDL-1 in human heart tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human PDL-1.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
CD274
B7H1
PDCD1L1
PDCD1LG1
PDL1
Purification Method
Antigen Affinity Purified
UniProt Number
Q9NZQ7
Molecular Weight
~30 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and 1 at ~33 kDa.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in Raji cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1 in 15 µg of Raji cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
