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Millipore Detect B-Cell-Activating Factor Receptor Using This Rabbit Polyclonal Antibody, Anti-Baff Receptor Antibody Validated For Use In Western Blotting & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Tumor necrosis factor receptor superfamily member 13C
B-cell-activating factor receptor
BAFF receptor
BAFF-R
BLyS receptor 3
CD268
Background Information
B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.
Product Information
Format
Affinity Purified
Control
Human, mouse, and rat spleen tissue lysates
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes the C-terminus of BAFF receptor.
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Gene Symbol
TNFRSF13C
BAFFR
BR3
Purification Method
Antigen Affinity Purified
UniProt Number
Q96RJ3
Molecular Weight
~22 kDa observed. Uniprot describes two isoforms at ~19 kDa. Uncharacterized bands may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.
Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
