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Millipore Anti-ATP-Citrate Synthase/Acly Antibody | Abc426 Is An Antibody Against ATP-Citrate Synthase/Acly Antibody For Use In Western Blotting, Immunohistochemistry. - Mill (Additional S&H or Hazmat Fees May Apply)
ATP citrate synthase, also known as ATP-citrate (pro-S-)-lyase (ACL) or Citrate cleavage enzyme, and encoded by the gene name ACLY is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-ATP-citrate synthase/ACLY Antibody | ABC426 is an antibody against ATP-citrate synthase/ACLY Antibody for use in Western Blotting, Immunohistochemistry.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ATP-citrate synthase/ACLY in human pancreas and human prostate tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human ATP-citrate synthase/ACLY.
Epitope
Unknown
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Rat
Mouse
Species Reactivity Note
Human, Rat, Mouse. Predicted to react with Porcine, Bovine, Sheep based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_001087
Gene Symbol
ACLY
Purification Method
Affinity Purfied
UniProt Number
P53396
Molecular Weight
~120 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in A549 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATP-citrate synthase/ACLY in 10 µg of A549 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
