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The protein named Angiopoietin-related protein 2 (ANGPTL2) or Angiopoietin-like protein 2 and encoded by the human gene named ANGPTL2/ARP2 is a secreted protein that is highly expressed in several tissues including the heart, spleen, stomach, colon, ovary and skeletal muscle. ANGPTL2 functions to induce endothelial cell sprouting in preparation for angiogenesis. ANGPTL2 is produced by endothelial cells and ANGPTL2 appears to function as an autocrine in helping to promote the sprouting response. ANGPTL2 also appears to use the same autocrine function in certain cancers and in particular in driving of metastasis. Recent research have demonstrated that tumor cell–derived ANGPTL2 increased in vitro motility and invasion in an autocrine/paracrine manner, conferring an aggressive metastatic tumor phenotype on the cells examined. Thus research is now focused on blocking the function of ANGPTL2 as one possible treatment for metastatic cancers. EMD-Millipore’s Anti-ANGPTL2 rabbit polyclonal antibody has been tested in western blot on mouse small intestine tissue extracts and in paraffin embedded immunohistochemistry on human heart tissue sections.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-ANGPTL2 antibody is validated for use in WB, IH for the detection of ANGPTL2.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ANGPTL2 in human heart sections tissue.
Biological Information
Immunogen
N-Trx, C-6XHis-tagged recombinant protein corresponding to human ANGPTL2.
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_036230
Gene Symbol
ANGPTL2
ARP2
Purification Method
Affinity Purfied
UniProt Number
Q9UKU9
Molecular Weight
~60 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in transfected HEK293 with ANGPTL2.
Western Blotting Analysis: A 1:250 dilution of this antibody detected ANGPTL2 in 10 µg of transfected HEK293 with ANGPTL2.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
