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Decapping and exoribonuclease protein (DOM3Z), also known as DXO, Dom-3 homolog Z, and encoded by the gene symbol DOM3Z/ DOM3L/ NG6, is a ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap. DOM3Z is part of a pre-mRNA capping quality control and has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. DOM3Z has a decapping activity toward incomplete 5 end cap mRNAs (such as unmethylated 5 end-capped RNA), which in return releases GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Additionally, DOM3Z has been implied to have RNA 5-pyrophosphohydrolase activity and to release pyrophosphates by hydrolyzing the 5 end triphosphate. DOM3Z is located in the nucleus, and expressed ubiquitously.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human DOM3Z.
Epitope
Unknown
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Mouse
Rat
Species Reactivity Note
Human, Mouse, Rat. Predicted to react with Bovine based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_005501
Gene Symbol
DXO
DOM3L
DOM3Z
NG6
Purification Method
Affinity Purfied
UniProt Number
O77932
Molecular Weight
~45 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human pancreas tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOM3Z in 10 µg of human pancreas tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
