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BRE1-A (E3 ubiquitin-protein ligase BRE1A) also known by its gene name hRNF20, plays a role in histone code and gene regulation as a component of the RNF20/40 E3 ubiquitin-protein ligase complex. That complex mediates monoubiquitination of Lys-120 of histone H2B,which is a specific tag for epigenetic transcriptional activation as well as a prerequisite for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation.
Product Information
Format
Affinity Purified
Control
A431 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This hRNF20 antibody is validated for use in WB for the detection of the hRNF20 protein.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human hRNF20.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_062538
Gene Symbol
RNF20
BRE1A
Purification Method
Affinity Purfied
UniProt Number
Q5VTR2
Molecular Weight
~113 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected hRNF20 in 10 µg of A431 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
