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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB, FC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABF114 |
| Description | Anti-MSR1/CD204 Antibody |
| Alternate Names |
|
| Background Information | Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimers disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC. |
| Key Applications |
|
| Application Notes | Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected MSR1/CD204 in 1X10E6 K562 myelogenous leukemia cells. |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the extracellular domain of human MSR1/CD204. |
| Epitope | Extracellular domain |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Affinity Purfied |
| UniProt Number |
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| Molecular Weight | ~42 & ~49 kDa observed. This antibody is predicted to cross-react with all isoforms of MSR1/CD204 (Isoform 1 - ~49 kDa, Isoform 2 - ~40 kDa, and Isoform 3 - ~42 kDa). |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in THP-1 cell lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected MSR1/CD204 in 10 µg of THP-1 cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |