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Cyclic GMP-AMP synthase (cGAS), also known as cGAMP synthase, H-cGAS, Mab-21 domain-containing protein 1, and encoded by the gene name MB21D1 and C6orf150, is a member of the MAB-21 family. Cyclic GMP-AMP synthase (cGAS) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. The catalysis process involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[g(2,5)PA(3,5)p]. Recent studies have indicated that Cyclic GMP-AMP synthase (cGAS) has an antiviral activity by acting as a key cytosolic DNA sensor, when the presence of double-stranded DNA (dsDNA) in the cytoplasm acts as a danger signal that triggers the immune responses. Cyclic GMP-AMP synthase (cGAS) then binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cyclic GMP-AMP synthase (cGAS) is expressed in the monocytic cell line THP1.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-cGAS antibody is validated for use in Western Blotting for the detection of cGAS.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human cGAS near the C-terminus.
Epitope
Near C-terminus
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Mouse
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_612450
Gene Symbol
MB21D1
C6orf150
Purification Method
Affinity Purfied
UniProt Number
Q8N884
Molecular Weight
~54 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in MDA-MB-231 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected cGAS in 10 µg of MDA-MB-231 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
