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Millipore Anti-Glur1 Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Glur1 & Has Been Tested In Western Blotting & Ihc (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.
Product Information
Format
Affinity Purified
Control
Rat brain tissue lysate
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1.
Epitope
Extracellular domain
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes the extracellular domain of GluR1.
Species Reactivity
Mouse
Rat
Human
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_113796
Gene Symbol
Gria1
Glur1
Purification Method
Affinity Purfied
UniProt Number
P19490
Molecular Weight
~110 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
