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Millipore This Ttbk1 Antibody Is Validated For Use In Wb & Ihc For The Detection Of The Ttbk1 Protein. - Mill (Additional S&H or Hazmat Fees May Apply)
Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.
Product Information
Format
Affinity Purified
Control
Jurkat cell lysate
Presentation
Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.
Quality Level
MQ100
Applications
Application
This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human TTBK1.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody is predicted to not cross-react with TTBK2.
Species Reactivity
Human
Mouse
Antibody Type
Polyclonal Antibody
Gene Symbol
TTBK1
Purification Method
Antigen Affinity Purified
UniProt Number
Q5TCY1
Molecular Weight
~143 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in Jurkat cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected TTBK1 in 15 µg of Jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
