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Millipore Anti-Picalm Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Phosphatidylinositol-Binding Clathrin Assembly Protein & Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Phosphatidylinositol-binding clathrin assembly protein
LAP
CALM
CLTH
Clathrin assembly lymphoid myeloid leukemia protein
Background Information
Phosphatidylinositol-binding clathrin assembly protein (PICALM), also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area as a component of the coated pit internalization machinery. PICALM fusion proteins have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia, and chromosomal aberrations are found in diffuse histiocytic lymphomas. PICALM is also expressed in neuronal synapses where it facilitates the endocytosis of VAMP2. PICALM variants are associated with Alzheimers disease and are thought to be involved in the endocytosis and recycling of the amyloid protein precursor (APP).
Product Information
Format
Affinity Purified
Control
EL4 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human PICALM.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody can recognize all isoforms of PICALM.
Species Reactivity
Mouse
Species Reactivity Note
Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
Antibody Type
Polyclonal Antibody
Gene Symbol
PICALM
Purification Method
Antigen Affinity Purified
UniProt Number
Q13492
Molecular Weight
~62 kDa and ~71 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~60 kDa and ~71 kDa.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in EL4 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PICALM in 15 µg of EL4 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
