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Millipore Anti-Jph3 Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Junctophilin-3 & Has Been Tested In Western Blotting, Ihc & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Junctophilin-3 (JPH3, JP-3), also known as Trinucleotide repeat-containing gene 22 protein (TNRC22), is a single-pass type IV membrane protein belonging to the junctophilin family. Junctophilins are important components of the junctional complexes which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. JPH3 is specifically expressed in brain. A mutation associated with JPH3 is the cause of Huntington disease-like type 2 (HDL2), a neurodegenerative disorder.
Product Information
Format
Affinity Purified
Control
Daudi cell lysate
Presentation
Purified rabbit polyclonal antibody in buffer containing PBS with 0.02% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence.
Key Applications
Western Blotting
Immunohistochemistry
Immunofluorescence
Application Notes
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected JPH3 in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected JPH3 in human brain cells.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to a sequence near the C-terminus of human JPH3.
Epitope
Near C-terminus.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes the C-terminus of JPH3.
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
JPH3
JP3
TNRC22
Purification Method
Affinity purified.
UniProt Number
Q8WXH2
Molecular Weight
~105 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and ~81 kDa. Uncharacterized bands may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting/Peptide Inhibition Assay in Daudi cell lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected JPH3 in 15 µg of Daudi cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
