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Millipore Anti-Dio3 Antibody Is An Antibody Against Dio3 Antibody For Use In Immunohistochemistry, Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
The enzyme DIO3 is a critical enzyme in thyroid hormone metabolism. It converts the thyroid hormone T4 into the inactive form RT3 and it also converts the thyroid hormone T3 into the inactive form T2. It is thought that DIO3 plays a role in preventing premature exposure of the developing fetus to adult levels of thyroid hormones. DIO3 also regulates the levels of fetal thyroid hormones during gestation, thus DIO3 is critical for proper development and metabolism of the fetus during embryological development. DIO3 is expressed in the placenta and in fetal tissues, and DIO3 is localized to the cell membrane and endosomal membranes. DIO3 is also often expressed in neoplastic tissues and in particular basal cell carcinomas.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Dio3 Antibody is an antibody against Dio3 Antibody for use in Immunohistochemistry, Immunofluorescence.
Key Applications
Immunohistochemistry
Immunofluorescence
Application Notes
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Dio3 in human placenta. Immunohistochemistry Analysis: A representative lot detected Dio3 in Hepatic tissue (Huang, S.A., et al. (2001). Journal of Clinical Endocrinology & Metabolism. 87(10):4457–4461). Immunohistochemistry Analysis: A representative lot detected Dio3 in human uterus, placenta, umbilical cord, fetal epithelial, and endometrium (Huang, S.A., et al. (2003). Journal of Clinical Endocrinology & Metabolism. 88(3):1384-1388).
Biological Information
Immunogen
BSA-conjugated linear peptide corresponding to the extracellular domain of human Dio3.
Epitope
Extracellular domain
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Species Reactivity Note
Human. Predicted to react with Primate based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
AAB35616
Gene Symbol
DIO3
ITDI3
TXDI3
Purification Method
Affinity Purfied
UniProt Number
P55073
Molecular Weight
34 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human uterus tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Dio3 in human uterus tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
