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Millipore Anti-Lnk/Sh2b Adapter Protein 3 Antibody
Millipore Anti-Lnk/Sh2b Adapter Protein 3 Antibody
List Price$542.08Your Price$542.08
Millipore Detect The Lnk/Sh2b Adapter Protein 3 Protein Using This Anti-Lnk/Sh2b Adapter Protein 3 Validated For Use In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Lnk is an SH2B3 multidomain adaptor protein that is primarily expressed in lymphocytes. It contains the characteristic pleckstrin homology (PH); src homology 2 (SH2); dimerization; and proline-rich domains. Lnk functions as a negative regulator of B cell proliferative processes via interaction with Jak2 and Mpl proteins, and inhibition of the PI3/Akt/STAT5 signaling pathway. Previous studies have implicated Lnk in celiac disease type 13.
Product Information
Format
Affinity Purified
Control
HepG2 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect the Lnk/SH2B adapter protein 3 protein using this Anti-Lnk/SH2B adapter protein 3 validated for use in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human Lnk/SH2B adapter protein 3.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes Lnk/SH2B adapter protein 3 at the C-terminus.
Species Reactivity
Human
Species Reactivity Note
Demonstrated to react with Human. Other homologies: Rat (78% sequence homology) and Mouse (72% sequence homology).
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_005466
Gene Symbol
SH2B3
LNK
Purification Method
Affinity Purfied
UniProt Number
Q9UQQ2
Molecular Weight
~80 kDa observed. The calculated molecular weight is 63 kDa, however Lnk/SH2B adapter protein 3 has been shown as a ~80 kDa band in western blots (Li, Y., et al. (2000). J Immunol. 164:5199-5206.)
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Lnk/SH2B adapter protein 3 on 10 µg of HepG2 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
