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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | IP, WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | CBL242 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Glucose Transporter GLUT-1 Antibody, CT |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | The polyclonal is presented in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Glucose Transporter GLUT-1 Antibody, C-terminus detects level of Glucose Transporter GLUT-1 & has been published & validated for use in IP & WB. |
| Key Applications |
|
| Application Notes | Western blot analysis of GLUT-1 activity in adipose and muscle tissue (5μg/mL) Immunoprecipitation of GLUT-1 (5μg/mL) Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | 12 amino acid peptide of the C-terminus of hGLUT-1 {LFHPLGADSQV} conjugated to KLH |
| Epitope | C-terminus |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | Specific for human glucose transporter 1 from muscle and adipose tissue. Does not cross-react with GLUT-4. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.[supplied by OMIM] |
| Gene Symbol |
|
| Purification Method | ImmunoAffinity Purified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P11166 # Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. SIZE: 492 amino acids; 54084 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. TISSUE SPECIFICITY: Expressed at variable levels in many human tissues. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: SwissProt: P11166 # Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly. SIMILARITY: SwissProt: P11166 ## Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. |
| Molecular Weight | 46 kDa |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |