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CD11c is the 150 kDa (Y-chain of the leucocyte integrin complex P1 50,95. The protein belongs to a family of related heterodimeric proteins designated CD11 in the classification system for human leucocyte differentiation antigens. The CD11 family shares a common 95 kDa li-chain (CD18). In addition to the p150,95 protein, this protein family contains two other members: leucocyte function associated-1 antigen (LFA-1, CD11a) and iC3b receptor (CD11b) (Hogg, 1997). CD11c is expressed strongly on monocytes and weakly on neutrophil granulocytes (Hogg, 1997). Natural killer cells and activated B and T cells also express CD11c (Luk, 1995). Anti-CD11c, KB90, was included in the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with the CD11c antigen (Hogg, 1997).
Product Information
Format
FITC
Control
PBMCs
Presentation
Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality Level
MQ100
Applications
Application
Milli-Mark Anti-CD11c-FITC Antibody, clone KB90 is an antibody against CD11c for use in FC.
Key Applications
Flow Cytometry
Biological Information
Immunogen
Hairy cell leukemia cells
Clone
KB90
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
Antibody recognizes Human CD11c antigen.
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_000878.2
Purification Method
Protein A Purfied
UniProt Number
P20702
Molecular Weight
150 kDa (Hogg, 1997)
Product Usage Statements
Quality Assurance
Evaluated by flow cytometry using human PBMCs
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.
