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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | FC | M | Phycoerythrin | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | FCMAB257P |
| Trade Name |
|
| Description | Milli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 |
| Alternate Names |
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| Background Information | Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. |
| Product Information | |
|---|---|
| Format | Phycoerythrin |
| Control |
|
| Presentation | Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 detects level of Glial Fibrillary Acidic Protein & has been published & validated for use in FC. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Purified glial filament (Debus, E., 1983). |
| Clone | GA5 |
| Host | Mouse |
| Specificity | Antibody recognizes Human Glial Fibrillary Acidic Protein. |
| Isotype | IgG1κ |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined |
| Gene Symbol |
|
| Purification Method | Protein A Purfied |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. SIZE: 432 amino acids; 49880 Da SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1. SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments. DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family. ... |
| Molecular Weight | 50 kDa Calculated |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by flow cytometry using U251 cells |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 tests |