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Millipore The Fibroblast Growth Factors (Fgfs) Are Heparin Binding Glycoproteins That Exert A Variety Of Biological Activities Toward Cells Of Mesenchymal, Neuronal & Epithelial Origin. - Mill (Additional S&H or Hazmat Fees May Apply)
Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue Number
GF172
Description
FGF-10 Protein, Human Recombinant, 25µg
Alternate Names
FGF10
Fibroblast Growth Factor 10
Keratinocyte growth factor 2
Background Information
The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF10 belongs to the subgroup of FGFs that also includes FGF3, 7, and 22. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-10 is most related to KGF/FGF-7 and is expressed during the development and preferentially in adult lungs. It signals through the FGFR 2b. Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.
Product Information
Presentation
Product is filtered through a 0.2 micron filter before lyophilization.
Quality Level
MQ100
Applications
Application
The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal & epithelial origin.
Biological Information
Purity
Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
Source
E. coli.
Cross Reactivity
None
UniProt Number
O15520
Product Usage Statements
Quality Assurance
Bioactivity assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF- receptors is ≤ 0.5 ng/mL, corresponding to a specific activity of ≥ 2 x 106 units/mg. Bioactivity assay #2: Determined by a cell proliferation assay using 4MBr-5 cells. The expected-ED50-for this effect is 0.5-15.0 ng/mL.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at -20°C for up to 6 months from date of receipt.
