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Millipore Tgf-Β-Iii (Transforming Growth Factor Beta Iii) Is One Of Three Closely Related Mammalian Members Of The Large Tgf-Β Superfamily. - Mill (Additional S&H or Hazmat Fees May Apply)
Product is endotoxin free (<0.1 ng/μg of protein (<1 EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses.
Description
Catalogue Number
GF176
Description
TGF-β-III Protein, Human Recombinant
Alternate Names
Transforming Growth Factor Beta 3
TGF-Beta-3
TGF-Beta-III
Background Information
TGF-β-III (transforming growth factor beta III) is one of three closely related mammalian members of the large TGF-β superfamily. TGF-β-I, TGF-β-II and TGF-β-III are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial mesenchymal transition. TGF-β3 regulates molecules involved in cellular adhesion and extracellular matrix formation during the process of palate development. TGF-β3 also plays an essential role in controlling the development of lungs in mammals and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. Recombinant TGF-β-III is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Product Information
Presentation
Product is filtered through a 0.2 micron filter before lyophilization.
Quality Level
MQ100
Applications
Application
TGF-β-III (transforming growth factor beta III) is one of three closely related mammalian members of the large TGF-β superfamily.
Biological Information
Purity
Product is endotoxin free (<0.1 ng/μg of protein (<1 EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses.
Source
E. coli.
Entrez Gene Number
7043
UniProt Number
P10600
Product Usage Statements
Quality Assurance
Determined by TGF-β-III’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at -20°C for up to 6 months from date of receipt.
