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Millipore Detect Eosinophil Peroxidase Using This Anti-Eosinophil Peroxidase Antibody, Clone Ahe-1 Validated For Use In Ic. - Mill (Additional S&H or Hazmat Fees May Apply)
Detect Eosinophil Peroxidase using this Anti-Eosinophil Peroxidase Antibody, clone AHE-1 validated for use in IC.
Key Applications
Immunocytochemistry
Application Notes
Final working dilutions must be determined by end user.
Biological Information
Clone
AHE-1
Host
Mouse
Specificity
Reacts specifically with human eosinophil peroxidase from eosinophils among peripheral blood cells. Eosinophil peroxidase is felt to play an important role in eosinophil function and perhaps endothelial injury in hypereosinophilic states.
COFACTOR: Binds 1 calcium ion per heterodimer (By similarity). & Binds 1 heme B (iron-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groups formed auto- catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232 was observed in 30% of the chains. SIZE: 715 amino acids; 81040 Da SUBUNIT: Tetramer of two light chains and two heavy chains. SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. DISEASE: SwissProt: P11678 # Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. SIMILARITY: SwissProt: P11678 ## Belongs to the peroxidase family. XPO subfamily.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
