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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | ELISA, FC, IP, ICC, IHC, FUNC | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB2146Z |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-ICAM-1 Antibody, clone P2A4, Azide Free |
| Alternate Names |
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| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Sterile-filtered lquid containing 0.2M phosphate buffer, 0.25M sodium chloride, no preservatives. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-ICAM-1 Antibody, clone P2A4, Azide Free is validated for use in ELISA, FC, IP, IC, IH, FUNC for the detection of ICAM-1. |
| Key Applications |
|
| Application Notes | Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue Immunocytochemistry: for use on B cells, PBL, T cells Immunoprecipitation FACS ELISA Inhibits ICAM-1 dependent adhesive interactions Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | IL-1beta activated HUVEC (human) |
| Clone | P2A4 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Human ICAM-1 |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | ICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor. |
| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses. SIZE: 532 amino acids; 57825 Da SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |