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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IHC, WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB3562 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Sodium/Iodine Symporter Antibody, clone 2-2 |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Liquid. Buffer = 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Sodium/Iodine Symporter Antibody, clone 2-2 detects level of Sodium/Iodine Symporter & has been published & validated for use in IH & WB. |
| Key Applications |
|
| Application Notes | Immunoblotting. The antibody recognizes a major band at ~97 kDa and minor bands at 15 kDa, 30 kDa, 68 kDa and 160 kDa. Immunohistochemistry on frozen tissues. Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide corresponding to amino acids 37-54 of human NIS. |
| Clone | 2-2 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Sodium/Iodide Symporter (NIS) |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | The sodium-iodide symporter (NIS), a member of the sodium/solute symporter family, actively transports iodide across the basolateral plasma membrane of the thyroid follicular cells.[supplied by OMIM] |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q92911 # Mediates iodide uptake in the thyroid gland. SIZE: 643 amino acids; 68666 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. DISEASE: SwissProt: Q92911 # Defects in SLC5A5 are the cause of iodide transport defect (ITD) [MIM:274400]. ITD is characterized by an inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland. It is a cause of congenital hypothyroidism. SIMILARITY: SwissProt: Q92911 ## Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C in undiluted aliquots for up to 6 months. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |