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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ch, H, M, R, Qu | WB, IHC | M | Ascites | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB364 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-MAP2A, 2B, 2C Antibody, clone HM-2 |
| Product Information | |
|---|---|
| Format | Ascites |
| Presentation | Ascites fluid. Liquid with 15 mm sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-MAP2A Antibody, 2B, 2C, clone HM-2 detects level of MAP2A & has been published & validated for use in WB, IH. |
| Key Applications |
|
| Application Notes | Immunoblotting at 1:500 using fresh rat brain extract or enriched microtubule protein preparation. Immunohistochemistry: 1:50 to 1:1000 Optimal working dilution must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Rat brain microtubule-associated protein. |
| Clone | HM-2 |
| Host | Mouse |
| Specificity | Shows selective staining of dendritic trees throughout the brain in immunohistochemical staining of brain tissue. In perkinje neurons, staining is restricted to the dendrites distal to the initial dendrite segment. No staining of cell body in mature Perkinje cells but strong staining of cell bodies of developing Perkinje cells from neonatal rats. No detectable staining of axons or non-neuronal cells. Reacts specifically with all forms of MAP2 (MAP2a ~280 kDa, MAP2b ~280 kDa and MAP2c ~70 kDa) as determined by immunoblot. No cross-reactivity observed to other MAPs or tubulin. |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. SIZE: 1827 amino acids; 199539 Da PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |