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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ca, H, M, R | ICC, IP, WB | M | Ascites | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB3741 |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Anti-Protein Tyrosine Phosphatase µ Antibody, clone SBK15 |
| Alternate Names |
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| Product Information | |
|---|---|
| Format | Ascites |
| Presentation | Ascites fluid. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Protein Tyrosine Phosphatase μ Antibody, clone SBK15 is validated for use in IC, IP, WB for the detection of Protein Tyrosine Phosphatase μ. |
| Key Applications |
|
| Application Notes | Western blot (1:1,000) Immunoprecipitation Immunostaining (1:200) Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Corresponds to amino acids 774-1452 of human PTPμ, purified from sf9 cells. |
| Clone | SBK15 |
| Host | Mouse |
| Specificity | Recognizes human PTPμ (Protein Tyrosine Phosphatase mu), a Receptor-type protein-tyrosine phosphatase. This antibody recognizes the cytoplasmic domain of PTPμ. |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. |
| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P28827 # Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. SIZE: 1452 amino acids; 163633 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P28827 ## Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 MAM domain. & Contains 2 tyrosine-protein phosphatase domains. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |