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Millipore This Anti-Dppa-2 Antibody, Clone 6c1.2 Is Validated For Use In Wb For The Detection Of Dppa-2. - Mill (Additional S&H or Hazmat Fees May Apply)
Pluripotent embryonic stem cell-related gene 1 protein
developmental pluripotency associated 2
Background Information
DPPA-2 (developmental pluripotency associated-2) is a novel Oct-4-related protein that is localized to the nucleus of mouse fetal germ cells. DPPA-2 has binding sites for both POU and Sox-2 protein domains and is expressed primarily in the developing germ line following gastrulation. These associations suggest that this protein participates in a very strong supportive role in maintaining cell pluripotentiality. In addition to its role as a pluripotency marker, more recent research using cancer cells suggests that DPPA-2 may also act as an embryo-cancer antigen—pointing to the presence of abnormal cell growth and the formation of cancerous cells.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-DPPA-2 Antibody, clone 6C1.2 is validated for use in WB for the detection of DPPA-2.
Key Applications
Western Blotting
Biological Information
Immunogen
Full length recombinant mouse DPPA-2 protein.
Clone
6C1.2
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This monoclonal antibody recognizes the mouse DPPA-2 protein.
Isotype
IgG2aκ
Species Reactivity
Mouse
Species Reactivity Note
Reacts with mouse. Reactivity with other species has not been tested.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
Q9CWH0
Gene Symbol
PESCRG1
Purification Method
Protein G Purified
UniProt Number
Q7Z7J5
UniProt Summary
FUNCTION: May play a role in maintaining cell pluripotentiality. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues. SEQUENCE SIMILARITIES: Contains 1 SAP domain.
Stem Cell Type
Mouse Embryonic Stem Cells
Molecular Weight
~34 kDa
Product Usage Statements
Quality Assurance
(Based upon representative data from a previous lot). Western Blotting: Recommended working concentration is 2 µg/mL.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
