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Millipore Mouse Anti-Stella Antibody Detects Level Of Stella & Has Been Published & Validated For Use In Elisa & Ic. - Mill (Additional S&H or Hazmat Fees May Apply)
Stella is specifically expressed by oocytes, pluripotent cells and primordial germ cells at the time of their emergence in gastrulating embryos, and is an important maternal factor in the cleavage stages of mouse embryos (Bortvin, 2004). The requirement for stella in germ cell specification remains controversial, however, most embryos from stella deficient mice failed to develop normally and rarely reach the blastocyst stage (Bortvin, 2004; Payer, 2003). The stella gene encodes a protein with an SAP-like domain and splicing factor motif-like structure, suggesting possible roles in chromosomal organization and RNA processing (Payer, 2003).
Product Information
Format
Purified
Presentation
Purified Ascites presented as a liquid in 0.02M phosphate buffer, 0.25M NaCI, pH 7.6 with 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Mouse Anti-Stella Antibody detects level of Stella & has been published & validated for use in ELISA & IC.
Key Applications
ELISA
Immunocytochemistry
Biological Information
Clone
3H5.2
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
Reacts with stella from human and mouse.
Isotype
IgG1
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_199286.2
Entrez Gene Summary
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
Gene Symbol
DPPA3
STELLAR
Stella
STELLA
stella
UniProt Number
Q6W0C5
UniProt Summary
FUNCTION: SwissProt: Q6W0C5 # May play a role in maintaining cell pluripotentiality. SIZE: 159 amino acids; 17851 Da SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). TISSUE SPECIFICITY: Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors. DEVELOPMENTAL STAGE: Expressed in fetal ovary.
Stem Cell Type
Human Embryonic Stem Cells
Mouse Embryonic Stem Cells
Induced Pluripotent Stem Cells
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8C in undiluted aliquots for up to 12 months.
