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Millipore Anti-Nmdar2b Antibody Detects Level Of Nmdar2b & Has Been Published & Validated For Use In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-NMDAR2B Antibody detects level of NMDAR2B & has been published & validated for use in WB.
Key Applications
Western Blotting
Application Notes
Western blot: 1:500-1:1,000 on rat brain lysate.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen
Recombinant protein from rat NMDAR2B.
Clone
1E4.25A4
Host
Mouse
Specificity
NMDAR2B, N-terminal. By Western blot the antibody reacts with bands at ~170 and ~48 kDa on rat brain lystate. An additional band at ~100 kDa may be seen depending on sample and antibody concentration used.
Isotype
IgG1
Species Reactivity
Mouse
Rat
Rabbit
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_000834.2
Entrez Gene Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
Gene Symbol
GRIN2B
MGC142180
Glutamate
NMDAR2B
NR3
NR2B
MGC142178
hNR3
UniProt Number
Q13224
UniProt Summary
FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. SIZE: 1484 amino acids; 166367 Da SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
