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Millipore This Anti-Rab27b, Clone 6c10.1 Antibody Is Validated For Use In Western Blotting And Immunohistochemistry (Paraffin) For The Detection Of Rab27b. - Mill (Additional S&H or Hazmat Fees May Apply)
RAB27B, also known as C25KG, is a member of the Rab GTPase superfamily. RAB27B acts as a lipid anchoring protein that is prenylated and works in vesicular fusion and protein trafficking within cells. The protein is most highly expressed in testis but can be expressed in other cell types as well. Because Rab27B is widely expressed in various tissues together with Rab27A and RAB27B has been found to have the ability to bind all of the Rab27A effectors that have been tested, Rab27A and Rab27B were initially thought to function redundantly by sharing common Rab27 effectors. However, recent evidence has indicated that by interacting with different Rab27 effectors Rab27A and Rab27B play different roles in special types of secretion (e.g. exosome secretion and mast cell secretion) even within the same cell type. Rab27B is particularly important for regulating protein secretion by pancreatic acinar cells, for instance.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Rab27B, clone 6C10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Rab27B.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab27B in human prostate and human uterus cancer tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Rab27B.
Clone
6C10.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_004154
Gene Symbol
RAB27B
Purification Method
Protein G Purified
UniProt Number
O00194
Molecular Weight
~25 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human prostate tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rab27B in 10 µg of human prostate tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
