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Millipore This Anti-Sphingosine 1-Phosphate Receptor 1 (S1p1) Antibody, Clone 8b7.1 Is Validated For Use In Western Blotting, Ihc For The Detection Of Sphingosine 1-Phosphate Receptor 1 (S1p1). - Mill (Additional S&H or Hazmat Fees May Apply)
Sphingosine 1-phosphate receptor 1(S1PR1 or S1P1), otherwise known as EDG1, is a g-protein coupled receptor which is activated by lysosphingolipid sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA). It is coupled to Gi-protein and MAP kinase signaling pathways, and may cooperate with other S1P receptors to regulate various cellular processes such as differentiation, actin remodeling, and migration. S1P1 is expressed in epithelial cells, fibroblasts, melanocytes, and smooth muscle cells.
Product Information
Format
Purified
Control
Mouse brain tissue lysate
Presentation
Purified mouse monoclonal IgG2a supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Sphingosine 1-phosphate receptor 1 (S1P1) Antibody, clone 8B7.1 is validated for use in Western Blotting, IHC for the detection of Sphingosine 1-phosphate receptor 1 (S1P1).
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Western Blot Analysis: A 1:500 dilution from a representative lot detected Sphingosine 1-phosphate receptor 1 (S1P1) in human brain tissue lysate.
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Sphingosine 1-phosphate receptor 1 (S1P1) in rat choroid plexus tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to mouse Sphingosine 1-phosphate receptor 1 (S1P1).
Clone
8B7.1
Host
Mouse
Isotype
IgG2a
Species Reactivity
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001391
Gene Symbol
S1PR1
CHEDG1
EDG1
Purification Method
Protein g Purified
UniProt Number
P21453
Molecular Weight
~40 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: A 1:1,000 diluiton of this antibody detected Sphingosine 1-phosphate receptor 1 (S1P1) in 10 µg of mouse brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
