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Millipore Detect Sphingosine 1-Phosphate Receptor 5 (S1p5) Using This Anti-Sphingosine 1-Phosphate Receptor 5 (S1p5) Antibody, Clone 13f9.1 Validated For Use In Western Blotting & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Sphingosine 1-phosphate receptor 5 (S1PR5 or S1P5), otherwise known as EDG8, is a g-protein coupled receptor which is activated by the lysosphingolipid sphingosine 1-phosphate (S1P). It is coupled to Gi/0 alpha and G12 signaling pathways. S1P5 is highly abundant in the brain, particularly in the corpus callosum, but S1P5 has also been detected in the spleen, placenta, lung, aorta, and peripheral blood leukocytes. In the brain, it regulates the transformation of radial glial cells into astrocytes, and the migration of oligodendrocyte precursor cells during development.
Product Information
Format
Purified
Control
Daudi cell lysate
Presentation
Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect Sphingosine 1-phosphate receptor 5 (S1P5) using this Anti-Sphingosine 1-phosphate receptor 5 (S1P5) Antibody, clone 13F9.1 validated for use in Western Blotting & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Sphingosine 1-phosphate receptor 5 in normal human cerebellum and normal placenta tissue.
Biological Information
Immunogen
Recombinant protein corresponding to mouse Sphingosine 1-phosphate receptor 5 (S1P5).
Clone
13F9.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Species Reactivity Note
Demonstrated to react with Human. Predicted to react with Mouse based on immunogen design.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001159687
Gene Symbol
S1PR5
EDG8
Purification Method
Protein g Purified
UniProt Number
Q9H228
Molecular Weight
~42 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in Daudi cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Sphingosine 1-phosphate receptor 5 in 10 µg of Daudi cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
