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Millipore Anti-Phosphoepitope Sr Proteins Antibody, Clone 1h4
Millipore Anti-Phosphoepitope Sr Proteins Antibody, Clone 1h4
List Price$511.84Your Price$511.84
Millipore Use Anti-Phosphoepitope Sr Proteins Antibody, Clone 1h4 (Mouse Monoclonal Antibody) Validated In Wb, Icc, Ip To Detect Phosphoepitope Sr Proteins Also Known As Ser-Arg-Rich Proteins. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-Phosphoepitope SR proteins Antibody, clone 1H4
Alternate Names
Ser-Arg-rich proteins
Background Information
Ser-Arg-rich (SR) proteins make up a family of functionally and structurally conserved phosphoproteins, and are required components of alternative and constitutive pre-mRNA splicing. SR proteins are characterized by their modular composition consisting of two domains of interest: an N-terminal RNA recognition motif (RRM) which serves in the determination of DNA-binding specificity, and the RS domain, an arginine and serine rich, C-terminal domain that serves as a shuttling and localization director of SR proteins and as a splicing activation domain. They are involved in various aspects of pre-mRNA splicing and in spliceosome assembly including; the identification and appropriation of splice-sites, and the manipulation of alternative splicing regulation.
Product Information
Format
Purified
Control
L6 plus insulin cell lysate
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Use Anti-Phosphoepitope SR proteins Antibody, clone 1H4 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect Phosphoepitope SR proteins also known as Ser-Arg-rich proteins.
Key Applications
Western Blotting
Immunocytochemistry
Immunoprecipitation
Application Notes
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC (Fukuhara, T., et al. (2006).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP (Buratti, E., et al. (2007).
Biological Information
Immunogen
Purified oocyte nuclei containing xenopus SR proteins.
Clone
1H4
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Rat
Mouse
Human
Species Reactivity Note
Demonstrated to react with rat. Predicted to react with mouse and human based on 100% sequence homology.
Antibody Type
Monoclonal Antibody
Gene Symbol
SR proteins
Purification Method
Protein G Purified
Molecular Weight
~ 75, 55, 40, 30, and 20 kDa observed. This antibody recognizes the family of SR proteins which consist of 75, 55, 40, 30, 20 kDa proteins.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in L6 plus insulin cell lysate.
Western Blot Analysis: 0.025 µg/mL of this antibody detected SR proteins in 10 µg of L6 plus insulin cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
